Acute pellagra in a child under treatment with isoniazid.

نویسندگان

  • M G PHILPOTT
  • H P PLAYER
چکیده

Toxic manifestations during isoniazid therapy are encountered in less than 5% of cases treated, and we have been able to trace little mention of them in children in the literature. The drug is now widely used in the treatment of tuberculosis and is universally prescribed as an adjuvant to streptomycin in tuberculous meningitis. The following case report concerns a child who developed pellagra late in the treatment for tuberculous meningitis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.

Eight cases of pellagra, diagnosed on the grounds of neuropathological findings and retrospective study of clinical data, were found among 106 necropsy cases of tuberculosis. Although these eight patients had shown various mental, neurological and gastrointestinal symptoms, as well as skin lesions, the diagnosis of pellagra had not been made clinically. In all the patients, pellagra symptoms ap...

متن کامل

Treatment of a Child with Refractory Acute Myeloid Leukemia with Humanized Anti-CD33 Monoclonal Antibody: A Case Report and Review of Drug Development

Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...

متن کامل

Half-and-half nail in a case of isoniazid-induced pellagra

Pellagra is a forgotten disease, particularly in developed countries. It is a nutritional disorder characterized by 4 “Ds”: diarrhea, dermatitis, dementia, and death. Causes of pellagra are chronic alcoholism, inadequate diet, malabsorption, metabolic derangement and drugs. Half-and-half nail is an occasional but specific clinical finding in chronic renal failure. We report a case of Isoniazid-...

متن کامل

Design and Optimization of a New Voltammetric Method for Determination of Isoniazid by Using PEDOT Modified Gold Electrode in Pharmaceuticals

Isoniazid (INH) was studied with regard to its electrochemical treatment on a strongly alkaline solution of a poly (3,4-ethylenedioxythiophene)-modified gold electrode, using both cyclic voltammetry and controlled potential techniques. This composite electrode exhibited 4-fold higher oxidation of INH, in accordance with peak densities, than the bare gold electrode. It was used the central compo...

متن کامل

Design and Optimization of a New Voltammetric Method for Determination of Isoniazid by Using PEDOT Modified Gold Electrode in Pharmaceuticals

Isoniazid (INH) was studied with regard to its electrochemical treatment on a strongly alkaline solution of a poly (3,4-ethylenedioxythiophene)-modified gold electrode, using both cyclic voltammetry and controlled potential techniques. This composite electrode exhibited 4-fold higher oxidation of INH, in accordance with peak densities, than the bare gold electrode. It was used the central compo...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Archives of disease in childhood

دوره 34 173  شماره 

صفحات  -

تاریخ انتشار 1959